教員紹介

氏名 川上 祐生 KAWAKAMI, Yuki
職位 准教授
E-Mail kawaka●fhw.oka-pu.ac.jp
研究室番号 6211

担当科目 生化学、代謝生化学、食品学実験Ⅰ、解剖生理学実験Ⅰ、生化学実験Ⅰ、生化学実験Ⅱ
研究目標 生活習慣病などの疾病による生体の変化を生化学的に捉え、その発症や進行の機序を明らかにするとともに、疾病を予防できるような食品や食品成分を探索する。
主な研究業績
  1. Y. Kawakami, M. Kinoshita, Y. Mori, S. Okochi, S. Hirano, I. Shimoda, K. Kanzaki, T. Suzuki-Yamamoto, M. Kimoto, M. Sugahara, T. Hori, H. Saino, M. Miyano, S. Yamamoto, Y. Takahashi
    The Y54(L)W mutation of anti-leukotriene C4 single-chain antibody increases affinity to leukotriene E4
    The Journal of Biochemistry, 161(1), 79-86 (2017).
  2. Y. Kawakami, T. Kiyosawa, S. Nakamura, K. Osada
    Effects of isoflavone supplementation on disturbances in lipid metabolism and antioxidant system due to exogenous cholesterol oxidation products in rats
    Journal of Functional Foods, 7, 212-218 (2014).
  3. Y. Kawakami, S. Hirano, M. Kinoshita, A. Otsuki, T. Suzuki-Yamamoto, M. Suzuki, M. Kimoto, S. Sasabe, M. Fukushima, K. Kishimoto, T. Izumi, T. Oga, S. Narumiya, M. Sugahara, M. Miyano, S. Yamamoto, Y. Takahashi Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies
    BBA - General Subjects, 1840(6), 1625–1633 (2014).
  4. Y. Kawakami, T. Hosokawa, T. Morinaka, S. Irino, S. Hirano, H. Kobayashi, A. Yoshioka, T. Suzuki-Yamamoto, M. Yokoro, M. Kimoto, H. Tsuji, H. Yamashita, S. Doi, C. Yutani, R. Kato, H. Itabe, T. Kanada, T. Hada, Y. Takahashi
    Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity
    Food Chem., 131(4), 1069-1075 (2012).
  5. Y. Kawakami, C. Yamashita, Y. Kashiwase, T. Morinaka, T. Suzuki-Yamamoto, H. Yamashita, M. Kimoto, H. Tsuji, Y. Kurahashi, H. Daiyasu, H. Toh, M. Sugahara, M. Miyano, S. Yamamoto, Y. Takahashi
    Functional expression of single-chain antibody to leukotriene C4
    Biochem. Biophys. Res. Commun., 392, 421-425 (2010).
  6. Y. Kawakami, N. Kubota, N. Ekuni, T. Suzuki-Yamamoto, M. Kimoto, H. Yamashita, H. Tsuji, T. Yoshimoto, M. Jisaka, J. Tanaka, H. F. Fujimura, Y. Miwa, and Y. Takahashi
    Tumor-suppressive lipoxygenases inhibit expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells
    Biosci. Biotech. Biochem., 73, 1811-1817 (2009).
  7. Y. Kawakami, T. Nakamura, T. Hosokawa, T. Suzuki-Yamamoto, H. Yamashita, M. Kimoto, H. Tsuji, H. Yoshida, T. Hada, Y. Takahashi
    Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms
    Prostaglandins Leukot Essent Fatty Acids, 80, 239-245 (2009).
  8. Y. Kawakami, T. Tsuzuki, K. Nakagawa, T. Miyazawa
    Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate
    Biosci. Biotech. Biochem., 71, 464-471 (2007).
  9. Y. Kawakami, W. Tsurugasaki, S. Nakamura, K. Osada
    Comparison of regulative functions between dietary soy isoflavones aglycone and glucoside on lipid metabolism in rats fed cholesterol
    J. Nutr. Biochem., 16, 205-212 (2005).
  10. Y. Kawakami, W. Tsurugasaki, Y. Yoshida, Y. Igarashi, S. Nakamura, K. Osada
    Regulative actions of dietary soy isoflavone on biological antioxidative system and lipid metabolism in rats
    J. Agric. Food Chem., 52, 1764-1768 (2004).

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