教員紹介

氏名 山本 登志子 YAMAMOTO, Toshiko
職位 教授
E-Mail toshiko●fhw.oka-pu.ac.jp
研究室番号 6209

専門分野 生化学・細胞組織学
担当科目
【学部】
生化学,生化学実験Ⅰ,生化学実験Ⅱ,代謝生化学,栄養学実習,総合演習Ⅲ,みぢかなバイオテクノロジー
【大学院】
分子組織化学特論,分子細胞生物科学特別講義
研究テーマ
  1. 生理活性脂質合成系をターゲットとした食品機能性の探索
  2. 中枢神経系における生理活性脂質合成酵素の生理的意義の解明
  3. 高機能性を有する嚥下食の開発
業績
  1. Suzuki-Yamamoto T, Tanaka S, Tsukayama I, Takafuji M, Hanada T, Arakawa T, Kawakami Y, Kimoto M, Takahashi Y. Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells. J. Clin.Biol.Nutri. 55(3), 162-167 (2014).
  2. Kiyokage E, Toida K, Suzuki-Yamamoto T, Kazunori I. Cellular localization of 5a-reductasein the rat cerebellum. J. Chem. Neuroanat. 59, 8-16, 2014.
  3. Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T; Suzuki M, Kimoto M, Sasabe S, Fukushima M, Kishimoto K, Izumi T, Oga T, Narumiya S, Sugahara M, Miyano M, Yamamoto S, Takahashi Y. Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. Biochim Biophys Acta. 1840, 1625-1633 (2014).
  4. Kawakami Y, Hosokawa T, Morinaka T, Irino S, Hirano S, Kobayashi H, Yoshioka A, Suzuki-Yamamoto T, Yokoro M, Kimoto M, Tsuji H, Yamashita H, Doi S, Yutani C, Kato R, Itabe H, Kanada T, Hada T, Takahashi Y. Antiatherogenic effect of guava leaf extracts inhibiting leukocyte-type 12-lipoxygenase activity. Food Chemistry, 131: 1069-75 (2012).
  5. Sato H, Isogai Y, Masuda S, Taketomi Y, Miki Y, Kamei D, Hara S, Kobayashi T, Ishikawa Y, Ishii T, Ikeda K, Taguchi R, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Suzuki-Yamamoto T, Yamamoto K, Murakami M. Physiological Roles of Group X Secreted Phospholipase A2 in Reproduction, Gastrointestinal Phospholipid Digestion, and Neuronal Function. J. Biol. Chem., 286(13):11632-48 (2011).
  6. Kunimoto A, Yokoro M, Murota K, Yamanishi R, Suzuki-Yamamoto T, Suzuki M, Yutani C, Doi S, Hiemori M, Yamashita H, Tsuji H, Kimoto M. Gastrointestinal Digestion and Absorption of Pen j 1, a Major Allergen from Kuruma Prawn, Penaeus japonicus. Biosci. Biotechnl. Biochem. 75(7):1249-58 (2011).
  7. Kawakami Y, Yamashita C, Kashiwase Y, Morinaka T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, Tsuji H, Kurahashi Y, Daiyasu H, Toh H, Sugahara M, Miyano M, Yamamoto S, Takahashi Y. Functional expression of single-chain antibody to leukotrien C(4). Biochem. Biophys. Res. Commun. 392(3):421-5 (2010).
  8. Suzuki-Yamamoto T, Toida K, Sugimoto Y, Ishimura K. Colocalization of prostaglandin F2alpha receptor FP and prostaglandin F synthase-I in the spinal cord. J. Lipid Res. 50, 1996-2003 and cover photo, (2009).
  9. Kawakami Y, Kubota N, Ekuni N, Kimoto M, Yamashita H, Tsuji H, Suzuki-Yamamoto T, Yoshimoto T, Jisaka M, Tanaka J, Fujimura HF, Miwa Y, and Takahashi Y. Tumor-suppressive lipoxygenases inhibit expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells. Biosci. Biotech. Biochem. 73(8) 1811-7 (2009).
  10. Kawakami Y, Nakamura T, Hosokawa T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, Tsuji H, Yoshida H, Hada T, Takahashi Y. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. Prostaglandins, Leukotrienes and Essential Fatty Acids 80(5-6) 239-45 (2009).
  11. Kawakami Y, Kubota N, Ekuni N, Kimoto M, Yamashita H, Tsuji H, Suzuki-Yamamoto T, Yoshimoto T, Jisaka M, Tanaka J, Fujimura H.F., Miwa Y, Takahashi Y. Tumor-suppressive lipoxygenases inhibit expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells. Biosci. Biotech. Biochem. 73(8) 1811-7 (2009).
  12. Suzuki-Yamamoto T, Sugimoto Y, Ichikawa A, Ishimura K, Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells. Histochem. Cell Biol. 28(4), 317-22 (2007).
  13. Kiyokage E, Toida K, Suzuki-Yamamoto T, and Ishimura K, Localization of 5a reductase in the Rat Main Olfactory Bulb. Journal of Comp. Neurol. 493(3), 381-395 (2005)
  14. Uezu K, Sano A, Sei H, Toida K, Houtani T, Sugimoto T, Suzuki-Yamamoto T, Takeshima H, Ishimura K, and Morita Y, Enhanced hippocampal acetylcholine release in nociceptin-receptor knockout mice. Brain Res. 1050, 118-123 (2005).
  15. Uezu K, Sei H, Sano A, Toida K, Suzuki-Yamamoto T, Houtani T, Sugimoto T, Takeshima H, Ishimura K, and Morita Y, Lack of a nociceptin receptor alters body temperature during the resting period in mice. Neuro. Report 15(5), 751-756 (2004).
  16. Suzuki-Yamamoto T, Toida K, Watanabe K, and Ishimura K, Immunocytochemical localization of prostaglandin F synthase II in the rat spinal cord. Brain Res. 969(1-2), 27-35 (2003).
  17. Suzuki-Yamamoto T, Toida K, Tsuruo Y, Watanabe K, and Ishimura K. Immunocytochemical localization of lung-type prostaglandin F synthase in the rat spinal cord. Brain Res. 877(2), 391-395 (2000).
  18. Suzuki T, Fujii Y, Miyano M, Chen LY, Takahashi T, and Watanabe K, cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase. J. Biol. Chem. 274, 241-248 (1999).
  19. Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, and Watanabe K, cDNA cloing, expression and characterization of human prostaglandin F synthase. FEBS Lett. 462, 335-340 (1999).
  20. Suzuki-Yamamoto T, Yokoi H, Tsuruo Y, Watanabe K, and Ishimura K, Identification of prostaglandin F-producing cells in the liver. Histochem. Cell Biol. 112, 451-456 (1999).
  21. Suzuki T, Watanabe K, Kanaoka Y, Sato T, and Hayaishi O, Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. Biochem. Biophys. Res. Commun. 241, 288-293 (1997).

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